Introduction: Transcatheter closure of patent ductus arteriosus ( PDA) in early infants remains a challenging procedure. We conducted a retrospective review of patients 4 months old who received transcatheter closure of PDA. Patients and methods: 14 Patients 4 months old who underwent transcatheter closure of PDA at the Samsung Medical Center between 2004 and 2016 were enrolled. The echocardiographic, angiographic images and medical records were reviewed. Results: The median age and body weight were 2 months and 4.3 kg, respectively. The narrowest duct diameter ranged from 2 to 6.5mm (median=3.3mm). PDA types based on Krichenko classification were A = 3 (23%), B = 2 (15%) and C = 8 (62%). Successful closure was confirmed in 11 patients (78%) on follow-up echocardiography. Among 11 successful cases, 9 Amplatzer devices and 2 vascular plug devices were used. Device size to duct ratio was ranged from 1.3-3. Out of three unsuccessful cases, device deployment made acquired significant coarctation in two cases. In another unsuccessful case, device was dislodged to descending aorta and removed by surgery. Local vascular complications occurred in 2 patients and one received common iliac vein allograft surgery because loss of vein was identified after sheath removal. Another case was successfully treated with intravenous heparin. Conclusion: Transcatheter closure of PDA in early infancy showed satisfactory outcomes in the considerable cases. However, it should be done with precaution with surgical back up due to high incidence of complications.